Seth says the big problem with nonprofit organizations is they resist change. I know I'm among the last to comment on The problem with non, but I beg to differ.
Fear of change is only our third worst problem.
Our #1 problem is hatred of fundraising and donors. Hardly any nonprofit was founded in order to raise funds. But most depend on fundraising to exist. This seems to fuel a sort of resentment of the craft and of donors that blocks effective, donor-focused communication. Organizations with this problem yearn for "better" donors that don't need the "demeaning" tactics of effective fundraising. They spend needless millions on this failed alchemy experiment.
The #2 problem is group-think. Nonprofit culture is so consensus-driven, that decisions can't be made until every possible stakeholder is satisfied. Which, of course, almost never happens.
(#4, if you're interested, is free and cheap services. See Stupid Nonprofit Ads.)
Yes, fear of change hobbles us. But it's entirely possible that some (maybe most) organizations shouldn't be using Twitter or whatever whiz-bang fad is amazing everyone. If you have the first two problems, you want get Twitter right anyway.